Bassi, Daniela; Mendes, Renata; Arakelian, Vivian; Caruso, Flávia; Cabiddu, Ramona; Júnior, José;
Arena, Ross; Borghi-Silva, Audrey.

Sports Medicine – Open, December 2016, Vol. 2 Issue: Number 1 p1-13, 13p;

Abstract: Concurrent aerobic and resistance training (CART) programs have been widely recommended as
an important strategy to improve physiologic and functional performance
in patients with chronic diseases. However, the impact of a
personalized CART program in patients with type 2 diabetes (T2D)
requires investigation. Therefore, the primary aim of the current study
is to investigate the impact of CART programs on metabolic profile,
glycemic control, and exercise capacity in patients with diabetes.
We evaluated 41 subjects with T2D (15 females and 19
males, 50.8 ± 7 years); subjects were randomized into two groups;
sedentary (SG) and CART (CART-G). CART was performed over 1.10-h
sessions (30-min aerobic and 30-min resistance exercises) three
times/week for 12 weeks. Body composition, biochemical analyses,
peripheral muscular strength, and cardiopulmonary exercise testing were
primary measurements.                   The glycated hemoglobin HbA1c
(65.4 ± 17.9 to 55.9 ± 12.7 mmol/mol), cholesterol (198.38.1 ± 50.3 to
186.8 ± 35.1 mg/dl), and homeostasis model assessment insulin
resistance (HOMA-IR) (6.4 ± 6.8 to 5.0 ± 1.4) decreased in the CART-G
compared to the SG. Although body weight did not significantly change
after training, skinfold measurement indicated decreased body fat in
the CART-G only. CART significantly enhanced muscle strength compared
to the SG (p< 0.05). CART was also associated with significant increase
in peak oxygen uptake and maximal workload compared to the SG
(p< 0.05).                   These data support CART as an important
strategy in the treatment of patients with T2D, producing both
physiologic and functional improvements.