Dear all
I should not be doing this but I hope that you will excuse me!Read the last abstract that I have just sent to you; the one about the 700 odd Olympic qualifyers. I was surprised; I wonder how many of you were!
My regards
Paul Older
Dear all
I should not be doing this but I hope that you will excuse me!Read the last abstract that I have just sent to you; the one about the 700 odd Olympic qualifyers. I was surprised; I wonder how many of you were!
My regards
Paul Older
Squeo, R;
Ferrera, A; Di Gioia, G; Mango, F; et al;
High blood pressure & cardiovascular prevention :
the official journal of the Italian Society of Hypertension,2025 Mar 14
Meziab, O; Department of Pediatrics (Cardiology), University of Arizona, Tucson, USA.
Dereszkiewicz, E; Guerrero, E; Hoyer, A;
Pediatric cardiology,2025 Apr
Patients with Fontan physiology have reduced exercise performance compared to their peers as well as a higher incidence of bundle branch block (BBB). This study aims to investigate the association between BBB and exercise performance in the Fontan population through a retrospective review of the Pediatric Heart Network Fontan study public use dataset. “Low Performers” were defined as ≤ 25th percentile (for Fontan patients) for each exercise parameter at anaerobic threshold (AT) for gender and age and “Normal Performers” were all other patients. A total of 303 patients with Fontan physiology who underwent exercise testing reached AT and had complete data for BBB. BBB occurred more frequently in Low Performers for VO 2 [OR (95% CI): 2.6 (1.4, 4.8)] and Work [OR (95% CI): 2.7 (1.4, 5.1)], suggesting that BBB in the Fontan population is associated with reduced exercise performance. This data adds to the existing clinical evidence of the adverse effects of conduction abnormalities on single ventricle cardiac output and adds support for consideration of cardiac resynchronization and multi-site ventricular pacing in this patient population.
Vanreusel, Inne; Department of Cardiology, Antwerp University Hospital, Edegem, Belgium.;
Hens, W; Van Craenenbroeck, E; Paelinck, B; et al;
Cardiology in the young,2025 Mar 11
Forbes, Lindsay; Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Aurora, CO, USA.
Bull, Todd; Lahm,Tim; Sisson,Tyler; et al;
Background Acute hypoxia increases pulmonary arterial (PA) pressures, though its effect on right ventricular (RV) function is controversial. The objective of this study was to characterize exertional RV performance during acute hypoxia.
Methods Ten healthy participants (34 ± 10 years, 7 males) completed three visits: visits 1 and 2 included non-invasive normoxic (fraction of inspired oxygen ( INLINEMATH ) = 0.21) and isobaric hypoxic ( INLINEMATH = 0.12) cardiopulmonary exercise testing (CPET) to determine normoxic/hypoxic maximal oxygen uptake ( INLINEMATH ). Visit 3 involved invasive haemodynamic assessments where participants were randomized 1:1 to either Swan-Ganz or conductance catheterization to quantify RV performance via pressure-volume analysis. Arterial oxygen saturation was determined by blood gas analysis from radial arterial catheterization. During visit 3, participants completed invasive submaximal CPET testing at 50% normoxic INLINEMATH and again at 50% hypoxic INLINEMATH ( INLINEMATH = 0.12).
Results Median (interquartile range) values for non-invasive INLINEMATH values during normoxic and hypoxic testing were 2.98 (2.43, 3.66) l/min and 1.84 (1.62, 2.25) l/min, respectively (P < 0.0001). Mean PA pressure increased significantly when transitioning from rest to submaximal exercise during normoxic and hypoxic conditions (P = 0.0014). Metrics of RV contractility including preload recruitable stroke work, dP/dt max , and end-systolic pressure increased significantly during the transition from rest to exercise under normoxic and hypoxic conditions. Ventricular-arterial coupling was maintained during normoxic exercise at 50% INLINEMATH . During submaximal exercise at 50% of hypoxic INLINEMATH , ventricular-arterial coupling declined but remained within normal limits. In conclusion, resting and exertional RV functions are preserved in response to acute exposure to hypoxia at an INLINEMATH = 0.12 and the associated increase in PA pressures.
KEY POINTS: The healthy right ventricle augments contractility, lusitropy and energetics during periods of increased metabolic demand (e.g. exercise) in acute hypoxic conditions. During submaximal exercise, ventricular-arterial coupling decreases but remains within normal limits, ensuring that cardiac output and systemic perfusion are maintained. These data describe right ventricular physiological responses during submaximal exercise under conditions of acute hypoxia, such as occurs during exposure to high altitude and/or acute hypoxic respiratory failure.
Schellenberg, Jana; Sports and Rehabilitation Medicine, University Hospital Ulm, Leimgrubenweg, Ulm, Germany.
Matits, Lynn; Bizjak, Daniel A; Deibert, Peter; et al;
Infection,2025 Feb 24
Fan, Yuxuan; Department of Cardiology Rehabilitation, Daqing Oilfield General Hospital, Daqing, Heilongjiang, China.
Sun, Xiaopeng;Li, Guihua;Wang, Xiaojing; et al;
Frontiers in cardiovascular medicine,2025 Feb 25
Scandinavian journal of medicine & science in sports [Scand J Med Sci Sports] 2025 Mar; Vol. 35 (3), pp. e70034.
High cardiorespiratory fitness (CRF) is associated with better overall health. This study aimed to find a metabolic signature associated with CRF to identify health-promoting effects. CRF based on cardiopulmonary exercise testing, targeted and untargeted metabolomics approaches based on mass spectrometry, and clinical data from two independent cohorts of the Study of Health in Pomerania (SHIP) were used. Sex-stratified linear regression models were adjusted for age, smoking, and height to relate CRF with individual metabolites. A total of 132 (SHIP-START-2: 483 men with a median age of 58 years and 450 women with a median age of 56 years) and 118 (SHIP-TREND-0: 341 men and 371 women both with a median age of 51 years) metabolites were associated with CRF. Lipids showed bidirectional relations to CRF independent of sex. Specific subsets of sphingomyelins were positively related to CRF in men (SM (OH) C14:1, SM(OH)C22:2 SM C16:0, SM C20:2 SM(OH)C24:1) and inversely in women (SM C16:1, SM C18:0, SM C18:1). Metabolites involved in energy production (citrate and succinylcarnitine) were only associated with CRF in men. In women, xenobiotics (hippurate, stachydrine) were related to CRF. The sex-specific metabolic signature of CRF is influenced by sphingomyelins, energy substrates, and xenobiotics. The greater effect estimates seen in women may emphasize the important role of CRF in maintaining metabolic health. Future research should explore how this profile changes with different types of exercise interventions or diseases in diverse populations and how these metabolites could be implemented in primary prevention settings.
Sumitani, Hitoshi; Department of Respiratory Medicine, NHO Osaka Toneyama Medical Center, Toyonaka, Japan.
Miki, Keisuke;Yamamoto, Yukio;Mihashi, Yasuhiro et al;
Respiratory care,2025 Mar 11
Background: Improving the anaerobic threshold (AT) provides benefits by avoiding overload, especially for patients with advanced COPD. However, the variables related to improving AT are poorly known. The aim of this study was to investigate which variables are related to improved AT after pulmonary rehabilitation (PR) using cardiopulmonary exercise testing (CPET).
Methods: Stable patients with severe and very severe COPD who performed 4-week PR and whose ATs were identified both before and after PR were selected; they were divided into two groups based on whether the AT increased after PR, and their responses were compared.
Results: In the 26 eligible subjects, there was no correlation between the mean change from baseline after PR in the inspired minus expired mean O 2 concentrations (ΔFO 2 ) and minute ventilation (V˙ E ) at peak exercise. Compared with the AT no-increase group, the AT increase group, at peak exercise, showed significant increases in peak oxygen uptake (V˙ O 2 ) and ΔFO 2 but not in V˙ E , after PR. The increase in V˙ O 2 at the AT after PR was well correlated with the mean change after PR in ΔFO 2 at peak exercise (r = 0.66, P < .001), rather than V˙ E . Of all the peaks and throughout exercise variables, ΔFO 2 at peak exercise was identified as one of the variables more closely correlated with improved AT after PR.
Conclusions: Improvement of ΔFO 2 at peak exercise, rather than V˙ E , correlated with an increased AT in subjects with advanced COPD, which suggests that improving ΔFO 2 independent of V˙ E may be a useful strategy to individualize PR.
Experimental physiology [Exp Physiol] 2025 Feb 21.
Date of Electronic Publication: 2025 Feb
Tidal breathing in awake humans is variable. This variability causes changes in lung gas stores that affect gas exchange measurements. To overcome this, several algorithms provide solutions for breath-by-breath alveolar gas exchange measurement; however, there is no consensus on a physiologically robust method suitable for widespread application. A recent approach, the ‘independent-breath’ (IND) algorithm, avoids the complexity of measuring breath-by-breath changes in lung volume by redefining what is meant by a ‘breath’. Specifically, it defines a single breathing cycle as the time between equal values of the INLINEMATH / INLINEMATH (or INLINEMATH / INLINEMATH ) ratio, that is, the ratio of fractional concentrations of lung-expired O 2 (or CO 2 ) and nitrogen (N 2 ). These developments imply that the end of one breath is not, by necessity, aligned with the start of the next. Here we demonstrate how the use of the IND algorithm fails to conserve breath-by-breath mass balance of O 2 and CO 2 exchanged between the atmosphere and tissues (and vice versa). We propose a new term, within the IND algorithm, designed to overcome this limitation. We also present the far-reaching implications of using algorithms based on alternative definitions of the breathing cycle, including challenges in measuring and interpreting the respiratory exchange ratio, pulmonary gas exchange efficiency, dead space fraction of the breath, control of breathing, and a broad spectrum of clinically relevant cardiopulmonary exercise testing variables. Therefore, we do not support the widespread adoption of currently available alternative definitions of the breathing cycle as a legitimate solution for breath-by-breath alveolar gas exchange measurement in research or clinical settings.