T. J. Siddiqi, Department of Medicine, Baylor University Medical Center, Dallas, TX, USA.
Y. Liu, F. Zannad, W. H. W. Tang, S. Solomon, J. Rosenstock, et al.

J Diabetes Complications 2025 Vol. 39 Issue 7 Pages 109059

AIMS: Assess the determinants of health status and its correlation with key parameters in individuals with diabetic cardiomyopathy (DbCM).
METHODS: In the ARISE-HF trial, the Kansas City Cardiomyopathy Questionnaire (KCCQ), cardiopulmonary exercise testing (CPET), Physical Activity Scale for the Elderly (PASE) score, echocardiographic, and laboratory assessments were performed at baseline in 691 persons with DbCM.
RESULTS: Study participants with lower KCCQ-Clinical Summary Score (CSS) were predominantly women, had poorer kidney function, higher body-mass index and natriuretic peptides, and lower hemoglobin levels. Lower KCCQ-CSS scores were associated with shorter CPET duration, lower peak exercise oxygen consumption (VO(2)) and lower PASE scores, but the correlations were weak (CPET duration: r = 0.14, 95 % CI: 0.07-0.22; peak VO(2): r = 0.21, 95 % CI: 0.14-0.28; PASE score: r = 0.19, 95 % CI: 0.11-0.26), indicating that although worse health status was linked to poorer function and activity, the strength of these relationships was limited. No meaningful associations were observed between KCCQ-CSS and echocardiographic measurements, cardiac biomarkers, or kidney function.
CONCLUSION: Health status in Stage B heart failure due to DbCM is frequently impaired. Among those with DbCM the KCCQ is only weakly correlated with the CPET parameters and PASE score implying these assessments provide unique information.