Nakano Y, Okumura N, Adachi S, Shimokata S, Tajima F, Kamimura
Y, Murohara T, Kondo T

Heart Vessels. 2017 Nov 15

Little is known regarding a correlation of hemodynamics at rest or exercise
capacity with echocardiographic parameters in patients with pulmonary
hypertension (PH). To clarify these potential correlations, we performed
transthoracic echocardiography, right heart catheterization, and cardiopulmonary
exercise testing in 53 patients with pulmonary arterial hypertension (PAH) and
chronic thromboembolic pulmonary hypertension (CTEPH). Left ventricular
end-diastolic dimension (LVDd), early diastolic velocity of the septal mitral
annulus (septal e’), tricuspid regurgitation peak gradient (TRPG), and tricuspid
annular plane systolic excursion (TAPSE) were significantly correlated with
cardiac index (LVDd; r = 0.477, P < 0.001, septal e’; r = 0.463, P = 0.001, TRPG;
r = – 0.455, P = 0.001 and TAPSE; r = 0.406, P = 0.003, respectively). Multiple
regression analysis revealed that LVDd and septal e’ were significantly
associated with cardiac index (CI) and stroke volume index at rest. Among the
exercise capacity markers evaluated, TAPSE, TRPG, and LVDd were significantly
correlated with peak oxygen uptake (TAPSE; r = 0.534, P < 0.001, TRPG;
r = – 0.466, P = 0.001 and LVDd; r = 0.411, P = 0.002, respectively). Multiple
regression analysis showed that TAPSE was significantly associated with peak
oxygen uptake (VO2). In PAH and CTEPH patients, LVDd and septal e’ were
significantly associated with CI at rest, whereas TAPSE was significantly
associated with peak VO2. Echocardiographic parameters may predict the prognostic
factors of PAH and CTEPH patients.