Phenotyping vasodilator responsiveness in idiopathic pulmonary arterial hypertension: any role for the cardiopulmonary exercise test?

Sivasubramaniam G; National Pulmonary Hypertension Service, Hammersmith Hospital, London, UK.;
Baccelli A; Haji G; Lo Giudice F; Weaver C; Howard L;Davies R;

ERJ open research [ERJ Open Res] 2025 May 27; Vol. 11 (3).
Date of Electronic Publication: 2025 May 27 (Print Publication: 2025).

Baseline PVR and PETCO 2 are independently associated with a positive acute vasoreactive response. Lower mean PAP and mean RAP, and higher RVEF, are seen when responders and non-responders are compared, independent of the degree of pulmonary vasculopathy.