Relationship between non‐invasive haemodynamic responses and cardiopulmonary exercise testing in patients with coronary artery disease

Sperling, Milena Pelosi Rizk; Caruso, Flávia Cristina Rossi;
Mendes, Renata Gonçalves; Dutra, Daniela Bassi; Arakelian, Vivian
Maria; Bonjorno, José Carlos; Catai, Aparecida Maria; Arena, Ross;
Borghi‐Silva, Audrey.

Clinical Physiology and Functional Imaging, March
2016, Vol. 36 Issue: Number 2 p92-98, 7p;

Abstract: Non‐invasive
assessment of haemodynamic function by impedance cardiography (IC)
constitutes an interesting approach to monitor cardiac function in
patients with coronary artery disease (CAD). However, such measurements
are most often performed at rest, whereas symptoms are also possible
during exertion, particularly at higher intensities. In addition, the
association between IC during exertion and cardiopulmonary exercise
testing (CPX) is not well understood in these patients, which was the
aim of this study. Nineteen men (age = 62 ± 6 years) with CAD [left
ventricular ejection fraction (LVEF) = 61 ± 10%] underwent a CPX using
an incremental protocol on a cycle ergometer, with simultaneous
measurement of IC. Cardiac output (CO), stroke volume (SV), cardiac
index (CI), peak oxygen consumption (VO2), the oxygen uptake efficiency
slope (OUES), circulatory power and ventilatory power were determined.
Pearson product‐moment correlation analysis revealed peak VO2 (r= 0·46)
was significantly related to CO. Peak oxygen pulse (0·52) was
associated with SV. OUES was associated with resting SV(0·47) and with
peak SV(r= 0·52). These findings suggest that ICindices are associated
with certain, but not all, established CPX measures in patients with
stable CAD.