Supervised exercise training reduces oxidative stress and cardiometabolic risk in adults with type 2 diabetes

a randomized controlled trial.

Vinetti, Giovanni; Mozzini, Chiara; Desenzani,
Paolo; Boni, Enrico; Bulla, Laura; Lorenzetti, Isabella; Romano,
Claudia; Pasini, Andrea; Cominacini, Luciano; Assanelli, Deodato.

Scientific Reports, March 2015, Vol. 5 Issue: Number 1 p9238-9238, 1p;

Abstract: To evaluate the effects of supervised exercise training (SET)
on cardiometabolic risk, cardiorespiratory fitness and oxidative stress
status in 2 diabetes mellitus (T2DM), twenty male subjects with T2DM
were randomly assigned to an intervention group, which performed SET in
a hospital-based setting, and to a control group. SET consisted of a
12-month supervised aerobic, resistance and flexibility training. A
reference group of ten healthy male subjects was also recruited for
baseline evaluation only. Participants underwent medical examination,
biochemical analyses and cardiopulmonary exercise testing. Oxidative
stress markers
(1-palmitoyl-2-[5-oxovaleroyl]-sn-glycero-3-phosphorylcholine [POVPC];
1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphorylcholine [PGPC]) were
measured in plasma and in peripheral blood mononuclear cells. All
investigations were carried out at baseline and after 12 months. SET
yielded a significant modification (p < 0.05) in the following
parameters: V’O2max(+14.4%), gas exchange threshold (+23.4%), waist
circumference (−1.4%), total cholesterol (−14.6%), LDL cholesterol
(−20.2%), fasting insulinemia (−48.5%), HOMA-IR (−52.5%), plasma POVPC
(−27.9%) and PGPC (−31.6%). After 12 months, the control group
presented a V’O2max and a gas exchange threshold significantly lower
than the intervention group. Plasma POVC and PGPC were significantly
different from healthy subjects before the intervention, but not after.

Conclusion, SET was effective in improving cardiorespiratory
fitness, cardiometabolic risk and oxidative stress status in T2DM.;