Distinct prognostic factors in patients with chronic heart failure and chronic kidney disease.

Sato T; Yamauchi H; Suzuki S; Yoshihisa A; Yamaki T; Sugimoto K; Kunii H;
Nakazato K; Suzuki H; Saitoh S; Takeishi Y.

International Heart Journal. 54(5):311-7, 2013.

Impaired renal function is a strong predictor of mortality in chronic
heart failure (CHF). However, the impact of chronic kidney disease (CKD)
on prognostic factors has not been rigorously examined in CHF. The purpose
of this study was to compare prognostic factors between CHF patients with
and without CKD. Consecutive 505 patients with CHF, who performed
cardiopulmonary exercise testing before discharge, were enrolled. Patients
were divided into two groups: CKD group (eGFR < 60 mL/minute/1.73 m2, n =
213) and non-CKD group (eGFR >= 60 mL/minute/1.73 m2, n = 292). The
patients were followed up to register cardiac events including cardiac
death and re-hospitalization due to worsening heart failure. There were
115 events during the follow-up period (746 +/- 238 days), and the cardiac
event rate was higher in the CKD group than in the non-CKD group (34%
versus 14%, P < 0.001). Multivariate Cox hazard analysis demonstrated that
body mass index (P < 0.001), log BNP (P < 0.001), peak VO2 (P < 0.05), and
left atrial dimension (P < 0.05) were independent parameters to predict
cardiac events after discharge in the non-CKD group. In contrast, peak VO2
(P < 0.01), log BNP (P < 0.01), and the concentrations of hemoglobin (P <
0.05) and uric acid (P < 0.05) were independent prognostic factors in the
CKD group. Prognostic factors were different between CHF patients with and
without CKD, and this should be considered when managing CHF patients with