Isocapnic buffering phase: a useful indicator of exercise endurance and prognosis in patients with coronary artery disease.

Yen YS, Su DCJ, Yuan KS et al

The Physician And Sportsmedicine [Phys Sportsmed] 2018 Jan 10. Date of Electronic Publication: 2018 Jan 10.

Objectives: The significance of the isocapnic buffering (IB) phase – the period between the first ventilatory threshold (1stVT) and respiratory compensation point (RCP) – has not been adequately established in patients. This study aimed to determine the clinical significance of the IB phase in coronary artery disease (CAD) patients.
Methods: This retrospective study included data of sixty-two CAD patients after coronary artery bypass graft (CABG) or percutaneous coronary intervention (PCI) performed in a single medical center between 2010-2014. According to their physical conditions, the patients performed incremental cardiopulmonary exercise test (CPET) using a cycle ergometer by the ramp of 5-20 W/min. Correlations between the corrected IB phase duration and age, body mass index (BMI), left ventricular ejection fraction (LVEF), and CPET parameters were evaluated using Pearson correlation coefficients. Variables predicting peak oxygen consumption (VO2) were evaluated using multiple regression.
Results: Peak VO2 (p < 0.001), VO2 at RCP (p < 0.001), ∆O2/∆WR slope (p < 0.001), maximal partial pressure of end tidal CO2 (PetCO2) (p = 0.0012), VE/VCO2 slope (p = 0.010), BMI (p = 0.012), and age (p = 0.017) were significantly correlated, whereas LVEF (p = 0.246) and VO2 at 1stVT (p = 0.179) were not significantly correlated with the corrected IB phase duration. In multiple regression analysis, the corrected IB phase duration, VO2 at 1stVT, and ∆O2/∆WR slope were significantly associated with peak VO2.
Conclusion: The findings indicate that the IB phase duration is a useful indicator of peripheral cardiopulmonary function, endurance performance, and prognosis in CAD patients.