Reference values for maximum oxygen uptake relative to body mass in Dutch/Flemish subjects aged 6-65 years: the LowLands Fitness Registry.

van der Steeg GE; Takken T;

European journal of applied physiology [Eur J Appl Physiol] 2021 Feb 01. Date of Electronic Publication:
2021 Feb 01.

Background: The maximum oxygen uptake (V2 max) during cardiopulmonary exercise testing (CPET) is considered the best measure of cardiorespiratory fitness.
Aim: To provide up-to-date reference values for the VO 2 max per kilogram of body mass (VO2 max/kg) obtained by CPET in the Netherlands and Flanders.
Methods: The Lowlands Fitness Registry contains data from health checks among different professions and was used for this study. Data from 4612 apparently healthy subjects, 3671 males and 941 females, who performed maximum effort during cycle ergometry were analysed. Reference values for the VO2 max/kg and corresponding centile curves were created according to the LMS method.
Results: Age had a negative significant effect (p < .001) and males had higher values of VO2 max/kg with an overall difference of 18.0% compared to females. Formulas for reference values were developed: Males: VO2 max/kg = - 0.0049 × age 2  + 0.0884 × age + 48.263 (R 2  = 0.9859; SEE = 1.4364) Females: VO2 max/kg = - 0.0021 × age 2  – 0.1407 × age + 43.066 (R 2  = 0.9989; SEE = 0.5775). Cross-validation showed no relevant statistical mean difference between measured and predicted values for males and a small but significant mean difference for females. We found remarkable higher VO2 max/kg values compared to previously published studies.
Conclusions: This is the first study to provide reference values for the VO2 max/kg based on a Dutch/Flemish cohort. Our reference values can be used for a more accurate interpretation of the VO2 max in the West-European population.